Environmental and genetic factors in age related hearing impairment
نویسندگان
چکیده
Age-related hearing impairment (ARHI), or presbycusis, is a complex disease with multifactorial etiology. It is the most prevalent sensory impairment in the elderly, and may have detrimental effects on their quality of life and psychological well-being. The aim of this paper is to give an overview of the current data on ARHI, focusing mainly on environmental agents and genetic predisposition in animal models and in humans. With improvement of our understanding of ARHI, treatment other than with amplification will be hopefully possible in the long term.
منابع مشابه
Gap Junction Protein Beta 2 Gene Variants and Non-Syndromic Hearing Impairment among Couples Referred For Prenatal Diagnosis in the Northeast of Iran
Introduction: Hearing impairment is a complex medical disorder whichhas genetic and non-genetic causes. Gap Junction Protein Beta 2 (GJB2) gene variant is a well-known disease-causing gene among patients with hearing impairment. The frequencies of genetic variants in the GJB2 gene are different in each population. This study aimed to discuss the GJB2 gene status in an Iranian population with he...
متن کاملتاثیر عوامل محیطی واختلالات ایمنی در ایجاد رفتارهای اوتیستیک
Background: Autism Spectrum Disorder (ASD) is a devastating, developmental disease and has several significant impacts on the patient’s life: impairment in social interactions as in both verbal and nonverbal behaviors, failing to develop relationships and respond to normal teaching methods, intellectual disabilities, and repetitive behaviors, being unable to instinctively ...
متن کاملRelationship between Smoking and Hearing Impairment of Automotive Industry Workers Exposed to Noise
Introduction: Working in noisy environments may cause hearing loss. Studies have shown that some factors along with noise are independently involved in hearing loss, one of which is cigarette smoking. The aim of this study was to evaluate the effects of smoking on hearing loss in workers exposed to occupational noise. Materials and Methods: The workers’ hearing loss was measured through a tona...
متن کاملA novel Z-score-based method to analyze candidate genes for age-related hearing impairment.
OBJECTIVE Approximately half of the variance of Age-Related Hearing Impairment (ARHI) is attributable to environmental risk factors, and the other half to genetic factors. None of these genes has ever been identified, but the genes involved in monogenic nonsyndromic hearing impairment are good candidates. Here we define and validate a quantitative trait value for ARHI, correcting for age and ge...
متن کاملاختلالات شنوایی در بیماران مبتلا به دیابت قندی
Background: A controversy exists on the prevalence of hearing impairment in diabetic patients. Previous studies have reported figures ranging from 0 to 93%.Methods: 80 diabetic patients (mean age: 49.0816 range: 16-65 years) were evaluated with regards to their hearing thresholds, using pure tone and speech audiometry. The results were compared with 78 healthy controls. None of the patients ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 10 شماره
صفحات -
تاریخ انتشار 2010